When the United States entered WWI in April 1917, the fledgling pharmaceutical industry had something they had never had before: a large supply of human test subjects. During the war years of 1918 to 1919, the US Army ballooned to 6 million men, of which 2 million were sent overseas. The Rockefeller Institute for Medical Research took advantage of this new pool of human guinea pigs to conduct vaccine experiments.
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